CPU in Gateway MX6446 is Turion64 2.0GHz, and in laptop Acer TravelMate 4202WLMI is Core Duo T2300 1.6GHz.
On both models screen size is 15.4".
If you think you will need more memory then you'll known than 1GB on Gateway MX6446 is better than 0.5GB on Acer TravelMate 4202WLMI.
Gateway MX6446 is something lighter with its weight of 2.86kg, comparing to 3kg at other laptop.
Video card inside MX6446 is ATI XPRESS 1150 and other laptop has Intel 950 inside.
These notebooks don't contain dedicated RAM for graphic cards, they use part of main memory for their graphic cards.
Gateway MX6446 had more hard disk space (100 GB) - definetly something which users who plan to hold movies on it will like.
Acer TravelMate 4202WLMI has faster hard disk (with 5400rpm).
For some small devices like mobile phones and cameras, you might need bluetooth communication which is internaly built only in Acer TravelMate 4202WLMI.
Infrared connection has only Acer TravelMate 4202WLMI.
No firewire on Acer TravelMate 4202WLMI unable them to connect to some camcorders.
Internal modem is available in both models and you will need it at some rare location without proper Internet connection.
Only Acer TravelMate 4202WLMI supports fast internet (1Gbit/s).
These notebooks have cardreaders inside them.
None has DVI output so you cannot connect them to some new LCD monitors.
Only TravelMate 4202WLMI has TV output.
These laptops aren't really suitable for Internet telephony since they haven't web camera.
MX6446 drives XP Media Center and TravelMate 4202WLMI drives XP Pro operating system.
Only Gateway MX6446 has special software pack : Works 8.5, Money 2006.
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